June 3, 2009 (Oxford, UK) — The authors of a new meta-analysis of aspirin use in primary prevention say their results “do not seem to justify general guidelines advocating the routine use of aspirin in all healthy individuals above a moderate level of risk for coronary heart disease. [1]“
The meta-analysis, published in the May 30, 2009 issue of theLancet, was conducted by the Antithrombotic Trialists’ (ATT) Collaboration, led by Dr Colin Baigent (Clinical Trial Service Unit, Oxford University, UK).
Baigent commented to heartwire : “The present data that we have reported here have not been previously available. The current guidelines are based on previous meta-analyses, which have limitations. We have shown for the first time that the very same people at higher risk of heart disease are also at higher bleeding risk with aspirin, which is a very important piece of information and should influence the way in which aspirin is used.”
He added: “Medicine has moved on in recent years, and we now know that we can safely reduce risk of heart disease by lowering cholesterol and blood pressure, and the drugs used to lower these risk factors are probably safer than aspirin. A person wanting to lower their risk might well consider taking a statin or an antihypertensive first and only after that add in a less safe drug like aspirin.”…read more here…
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