Coffee and Tylenol Toxic? April 22, 2008
Posted by healthandsurvival in Survival, Wellness, health, medicine.Tags: coffee, health, liver, medicine, toxicity, tylenol
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(NaturalNews) Combining caffeine with the active ingredient in Tylenol (acetaminophen) may be extremely dangerous for the liver, according to new research conducted at the University of Washington and reported in the journal Chemical Research in Toxicology.
Researchers performed the study on E. coli bacteria that had been genetically modified to produce a human liver enzyme that breaks down the pain killing chemical paracetamol, also known as acetaminophen. A toxic byproduct of this enzyme’s activity is what leads to liver damage in cases of paracetamol overdose.
When the scientists expose the bacteria to a large combined dose of caffeine and paracetamol, production of the toxic byproduct tripled. According to researchers, this translates to three times the risk of permanent liver damage.
According to British health expert Dr. Simon Thomas of the University of Newcastle, paracetamol is the culprit in 40 percents of drug overdoses in the United Kingdom, leading to 100 deaths or liver transplants yearly. But Thomas said that it would be hasty to draw too many conclusions about the human liver from a study conducted on bacteria.
“There are a million miles between E. coli and humans in terms of how paracetamol and caffeine are metabolized,” he said.
Prior studies have shown that caffeine exacerbates paracetamol-induced liver damage in rats, and that mixing alcohol with the painkiller intensifies its effects on the liver. However, this is the first study to provide evidence that a mix of paracetamol and caffeine may be dangerous.
But the researchers noted that the doses they used in the study were enormous, and that there is as yet no evidence what dose would be required to be dangerous to humans. Because of this uncertainty, however, they advised caution in mixing the two drugs.
“The bottom line is that you don’t have to stop taking acetaminophen or stop taking caffeine products, but you do need to monitor your intake more carefully when taking them together, especially if you drink alcohol,” said researcher Sid Nelson.
Widespread Ghostwriting of Drug Trials Means “Scientific” Credibility of Pharmaceutical Industry is a Sham April 22, 2008
Posted by healthandsurvival in Diseases, Drugs.Tags: Drugs, pharmaceutical. medicines
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(NaturalNews) The discovery that drug companies have been ghostwriting scientific studies using in-house writers, then paying (bribing) doctors and high-level academics to pretend they were the author of the article is making shockwaves across conventional medicine. This latest revelation of scientific fraud exposes a massive, widespread system of fraud involving not only the drug companies, but also hundreds of different peer-reviewed, “scientific” medical journals that have published these ghostwritten articles. This scam is the latest embarrassment to conventional medicine; a system built on such a foundation of scientific fraud that the admission of dishonesty no longer surprises anyone. The pharmaceutical industry, it seems, is now supported almost entirely by fraudulent science fabricated by marketing personnel.
Remember, it is these studies — the very ones now discovered to be ghostwritten by Big Pharma’s in-house authors — that the FDA uses to approve these drugs, unleashing them onto the public where potentially hundreds of millions of doses of the drug may be sold in just the first few years of its approval. But what we’re learning now is that the whole system is an elaborate scam. For these studies, there’s no real science involved at all.
To back this up, let me explain how this scam works in seven simple steps:
Step 1: A drug company runs an in-house study (using fraudulent study design from the start) to “prove” that their drug is both safe and effective. If the study produces negative results, it is thrown out. If it produces positive results, proceed to step 2.
Step 2: That same drug company uses in-house writers (“ghost writers”) to write up the results of the study in a favorable light by discarding any data that doesn’t fit the desired outcome. Note that these in-house writers are marketing people, not doctors or scientists, and they are on Big Pharma’s payroll!
Step 3: The drug company contacts a noted doctor or academic and offers to pay them a bribe (a “writing fee”) to put their name on the paper as if they were the original author. In reality, the paper has already been completely written and the doctor needs to write nothing.
Step 4: The paper is submitted to peer-reviewed academic journals (such as JAMA) for publication. Since the paper appears to have been independently written by an outside scientist or doctor, the journal is far more likely to consider it credible. Thus, it gets more easily published. The drug company reveals nothing about the true origins of the paper.
Step 5: The drug company that sponsored all this forwards the peer-reviewed, published study to the FDA, claiming this is now “scientific fact” that proves their drug is both safe and effective. Since the study was published in a peer-reviewed medical journal, it must be true, right?
Step 6: The FDA, which conducts no drug safety studies of its own, automatically believes the conclusions of the study (since it was published in a credible journal, after all), and therefore approves the drug for sale! From there, the FDA claims its decisions are based on the “gold standard of evidence-based medicine!”
Step 7: Once the drug is approved by the FDA, the drug company then claims the drug has been declared safe and effective by an independent government agency, and therefore the drug must indeed be both safe and effective. In other words, even though the drug company fabricated much of the evidence used by the FDA to make their approval decision, the drug company still claims that the FDA’s decision is an independent, science-based approval of their drug! Furthermore, the drug companies are now arguing that FDA approval should immunize them from any lawsuits or claims of harm stemming from their drugs. Amazing, huh?
From here, doctors are medical personnel are taught that the drug is backed by good science and that the FDA has independently reviewed the evidence and approved the drug. Therefore, it’s safe to prescribe to patients. What nobody has been told, however, is that the entire process — from the drug studies to drug approvals — was fabricated!
Or, put another way, as long as ghostwriting is tolerated in conventional medicine, the pharmaceutical industry has lost all credibility and is now clearly based on science fraud and marketing gimmicks, not genuine evidence. And remember, ghostwriting is not a new issue. It’s been going on for decades. The only thing new about this issue is that it has been exposed in once-secret court documents that just happened to come out during a recent Merck trial.
Medical Journals Should Retract All Ghostwritten Articles
NaturalNews is now calling for all peer-reviewed medical journals to determine the true authorship of all scientific articles they’ve published over the last ten years and retract all ghostwritten articles.
That would be quite a list, likely involving tens of thousands of published studies. The medical journals, of course, won’t bother with that process. You know why? Because just like the drug companies, they’d rather sweep their scientific fraud under the rug than admit they’ve been played by Big Pharma or participated in a massive campaign of scientific fraud that now calls into question the credibility of virtually all medical journals (except for PLoS Medicine, of course, which remains independent and honest).
You see, all the big players were in on this scam: The drug companies, the medical journals, the FDA, the researchers and even the doctors and academics who accepted as much as $25,000 per study to slap their name on a paper already written by Big Pharma’s in-house marketing writers. I guess credibility is cheap in conventional medicine. The entire reputation of a doctor can be purchased for as little as $10,000. Similarly, the integrity of the entire industry can be bought with Big Pharma’s dollars. There’s nothing in modern pharmaceutical medicine that isn’t for sale… not even scientific credibility.
The FDA Should Retract its Approval of All Drugs Based on Ghostwritten Studies
Think about this: The evidence used by the FDA to approve drugs is now known to be tainted. If this were a state or federal court, that evidence would be thrown out as being “inadmissible.” But at the FDA, there’s no such thing as pro-drug evidence that’s too tainted to accept as fact. (There are truly zero standards for scientific evidence at the FDA, at least with the top decision makers. They can accept any piece of fraudulent evidence as fact, no matter how “poisoned” the evidence might be.)
Based on what we now know, the FDA needs to retract its approval of numerous drugs that were approved based on ghostwritten papers. In other words, if the FDA’s original approval of these drugs was based on scientific fraud, then the FDA needs to rectify the situation and withdraw the approval of those drugs until proper studies can be conducted.
Will the FDA engage in such retractions? Of course not. There’s not motivation to do so. The FDA isn’t interested in good science or protecting the public. It’s only interested in boosting Big Pharma’s profits using whatever methods of collusion, corruption and scientific fraud it can get away with.
I say that if the FDA refuses to retract the approvals of drugs based on ghostwritten studies, the FDA has zero remaining credibility and has abandoned anything resembling “evidence-based medicine.” In other words, the FDA is a willing partner in this widespread campaign of scientific fraud, and even when the fraud is discovered, the FDA does nothing to attempt to reestablish scientific credibility. Real science, it seems, has zero priority at the FDA.
The Pharmaceutical Racket
So now we have Big Pharma, the FDA and the top medical journals all engaged in a massive conspiracy to deceive the public, to win approval for dangerous drugs, and to prop up the pharmaceutical industry with fabricated evidence on drug safety that was actually written by Big Pharma’s in-house marketing writers. This is clearly a grand pharmaceutical racket, operated much like a system of organized crime. Except these criminals, it seems, have not yet been arrested and charged with any crimes. (That day is coming, however…)
Now I ask you this: How stupid are doctors if they still believe in all this fabricated evidence? Because I’ve met a lot of M.D.s who believe so strongly in the “evidence” behind pharmaceuticals that they’ll argue your ears off about the science of pharmaceuticals vs. the “wishful thinking” of nutritional supplements. It makes you wonder just how gullible doctors really are. (In truth, they’re incredibly gullible. All it takes is a visit by a young, bubbly drug rep wearing a push-up bra to radically alter the brand-name drug prescribing habits of a typical M.D.)
And how gullible are patients who believe Big Pharma or the FDA? To believe in this system of fraudulent “junk” science and manipulated clinical trials is downright foolish. And yet hundreds of millions of Americans take pharmaceuticals every single day — drugs that make them no healthier and that, in fact, may harm them or kill them.
Folks, it is time for the United States of America to wake up and realize we’ve all been conned by Big Pharma. We’ve been hoodwinked by a band of clever hucksters sporting academic degrees and authoritative-sounding titles. We’ve been had. Let us now end this foolishness by retracting all published studies based on fraudulent ghostwriting, retracting all FDA-approved drugs based on these fraudulent studies, and prosecuting the top pharmaceutical companies for the widespread fraud they have so cleverly designed and unleashed in pursuit of the almighty dollar. It is time to invoke established federal anti-trust laws and go after these companies, putting them out of business once and for all and thereby saving countless American children, adults and senior citizens from death by dangerous pharmaceuticals.
$10 for a loaf of bread? Hyperinflation? April 21, 2008
Posted by healthandsurvival in Politics and Medicine, Society, Survival.Tags: bread, food, inflation, Survival
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Economist Walter Williams Sees Hyperinflation As Early As 2010
Economist Walter (John) Williams issued a special report on the evolving hyperinflation that he sees coming into the U.S. as early as 2010. Such a claim may seem incredible to most of us who have never lived in such an environment and have enjoyed the benefits of economic and political stability all our lives. To be sure, we have experienced some uncomfortable times like the deep but short-lived recession of 1981-82 and the double-digit inflation ofthe 1970 Carter Presidency. But I believe Williams makes a very, very strong case for hyperinflation with the dynamics driving it very much like that of theGerman Weimar Republic. Williams shows how it will be absolutelyimpossible for the U.S., as a massive debtor nation, to meet its trillions ofdollars of obligations going forward, given: (a) foreign savers bailing out ofthe U.S. dollar, and (b) the obligations ….read rest of story
Dying 47-Year-Old Professor Gives Exuberant ‘Last Lecture’ April 21, 2008
Posted by healthandsurvival in Diseases, Survival, Wellness, health.Tags: cancer, death, disease, health, hope, Life, news
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Randy starts talking about 8:30 into the video. This is an amazing video. Dr. Pausch discusses how to live life to its fullest. He is currently dying of pancreatic cancer. You can see his personal website here: http://download.srv.cs.cmu.edu/~pausch/news/index.html
Oldest Person Turns 115 Years Old April 20, 2008
Posted by healthandsurvival in Diseases, Longevitiy, Survival, Wellness.Tags: 100, centenarian, health, Life, live, Longevitiy, news, old
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Is it her genes? Oldest known person turns 115 on Sunday
By RICK CALLAHAN, Associated Press Writer
Maybe it was a lifetime of chores on the family farm that accounts for Edna Parker’s long life. Or maybe just good genes explain why the world’s oldest known person will turn 115 on Sunday, defying staggering odds.
Scientists who study longevity hope Parker and others who live to 110 or beyond — they’re called supercentenarians — can help solve the mystery of extreme longevity.
“We don’t know why she’s lived so long,” said Don Parker, her 59-year-old grandson. “But she’s never been a worrier and she’s always been a thin person, so maybe that has something to do with it.”
On Friday, Edna Parker laughed and smiled as relatives and guests released 115 balloons into sunny skies outside her nursing home. Dressed in pearls, a blue and white polka dot dress and new white shoes, she clutched a red rose during the festivities.
Two years ago, researchers from the New England Centenarian Study at Boston University took a blood sample from Parker for the group’s DNA database of supercentenarians.
Her DNA is now preserved with samples of about 100 other people who made the 110-year milestone and whose genes are being analyzed, said Dr. Tom Perls, an aging specialist who directs the project.
“They’re really our best bet for finding the elusive Holy Grail of our field — which are these longevity-enabling genes,” he said.
Only 75 living people — 64 women and 11 men — are 110 or older, according to the Gerontology Research Group of Inglewood, Calif., which verifies reports of extreme ages.
Parker, who was born April 20, 1893, was recognized by Guinness World Records as the oldest of that group last August after the death of a Japanese woman four months her senior.
A widow since her husband, Earl, died in 1938 of a heart attack, Parker lived alone in their farmhouse until age 100, when she moved into her son Clifford’s home. She cheated death a few months later.
One winter night, Clifford and his wife returned home from a high school basketball game to find her missing. Don, their son, says he discovered his grandmother in the snowy darkness near the farm’s apple orchard. He scooped up her rigid body and rushed back to the house.
“She was stiff as a 2-by-4. We really thought that was the end of her,” he said.
But Parker recovered fully, suffering only frostbitten fingertips.
Fifteen years later, her room at the Heritage House Convalescent Center in Shelbyville, Ind., about 25 miles southeast of Indianapolis, is adorned with teddy bears and photos of her five grandchildren, 13 great-grandchildren and 13 great-great grandchildren. She’s outlived her two sons, Clifford and Earl Jr.
During a visit this week, Parker was captivated by a new album of photos and documents from her life that Don’s wife, Charlene, had assembled.
“That’s the boys,” she said hoarsely, tapping a photo of her two late sons in their youth. “Clifford and Junior.”
Her two sisters also are deceased. Georgia lived to be 99, while her sister Opal was 88 when she died.
Parker’s long-lived sisters are typical of other centenarians, according to Dr. Nir Barzilai, director of the Albert Einstein College of Medicine’s Institute for Aging Research in New York. Nearly all of them have a sister, mother or other relative who lived a long life, he said.
“Longevity is in the family history,” Barzilai said.
He and other scientists have found several genetic mutations in centenarians that may play a role in either slowing the aging process or boosting resistance to age-related diseases.
Perls said the secret to a long life is now believed to be a mix of genetics and environmental factors such as health habits. He said his research on about 1,500 centenarians hints at another factor that may protect people from illnesses such as heart attacks and stroke — they appear not to dwell on stressful events.
“They seem to manage their stress better than the rest of us,” he said.
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On the Net:
New England Centenarian Study: http://www.bumc.bu.edu/centenarian
