Do Epilepsy Drugs Increase Risk For Suicide?

The agency posted a warning on its web site this afternoon about an increased risk of suicidal thoughts and behaviors associated with 11 drugs used to treat epilepsy and certain psychiatric disorders. The drugs include Pfizer’s Lyrica, which is approved for treating pain associated with diabetes and fibromyalgia; Johnson & Johnson’s Topamax, which is also approved to treat migraines; and Glaxo’s Lamictal.“Patients who were treated for epilepsy, psychiatric disorders, and other conditions were all at increased risk for suicidality when compared to placebo, and there did not appear to be a specific demographic subgroup of patients to which the increased risk could be attributed. The relative risk for suicidality was higher in the patients with epilepsy compared to patients who were given one of the drugs in the class for psychiatric or other conditions,” the FDA wrote… entire story

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